These chromosomes are of special interest because they code for proteins that play a crucial role in mesothelioma including ISG genes such as RSAD2, IFI44, and OAS2 (Chr2, Chr1, and Chr 12 respectively) or DNA damage-related genes CHEK2 and MSH2 (Chr 22 and Chr 2) and MSLN on Chr 16. This evidence concerns the gene MSLN and mesothelioma.