P4HA2 and malignant colon neoplasm: We explored the effects of P4HA2, HIF-1α, and HILPDA in colon cancer cell lines, the results suggested that overexpression of P4HA2, HIF-1α, and HILPDA promoted lipid droplet accumulation in colon cancer cells by reducing ATGL enzyme activity (Figs. S6A–E) and promoted the proliferation and migration of colon cancer cells (Figs. S6F–J).