Transcripts for several candidate genes for obesity were absent in the whole brain or absent in specific regions of the brain (Cyp17a1, Gdf15, Gpr151, Lmx1b, Olig3, Sbk1, Sim1, Skor1, Tnni3k). The gene discussed is OLIG3; the disease is obesity due to melanocortin 4 receptor deficiency.