Using a list of candidate genes previously used to annotate risk genes expressed in the mouse brain [49], we show predominant expression of candidate genes for obesity in hypothalamus (Asb4, Calcr, Cbln1, Pomc, Sim1), hippocampus (Bdnf, Grp), striatum (Cep295, Rarb) or in brainstem (Fam57b, Gprc5b, Tfap2b) (Supplementary Table 9). The gene discussed is POMC; the disease is obesity disorder.