To further explore the functions of these cancer-specific eccEnhancers, we annotated the closest active genes of super-enhancers carried by cancer-specific eccEnhancers and found that these target genes were enriched in some cancer-related pathways, such as the PI3K-Akt signaling pathway, MAPK signaling pathway and pathways in cancer (Fig. 4B) [29, 30]. This evidence concerns the gene AKT1 and cancer.