In this observation, the polymorphism of the rs41423247 locus on the NR3C1 gene and the rs324420 locus on the FAAH gene in children with epilepsy were detected, and the relationship between them and drug response in children with epilepsy was analyzed, so as to understand the clinical significance of these genetic polymorphisms in improving treatment outcomes for children with epilepsy. The gene discussed is FAAH; the disease is epilepsy.