Additional treatment with anti-VSIG4 antibody in VSIG4-KO mice slightly improved the anti-tumor effect compared with untreated VSIG4-KO mice (Fig. 1F-G, S2, A-E), indicating that VSIG4 expression by the host immune cells, not the tumor cells, was the major factor mediating immune evasion. This evidence concerns the gene VSIG4 and neoplasm.