Therefore, the results from studies with use of only VHL+ ccRCC cell line (Studies 5 and 12 in Table 1) [72] or mixed use of VHL+ and VHL− cell lines (Study 13 in Table 1) [91], or mixed use of ccRCC and pRCC cell lines (Studies 6, 13, and 14 in Table 1) [70, 90], are difficult to extrapolate with relevance to clinical ccRCC [95]. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.