Given the role of lncRNAs in cancer progression and their high enrichment in PM-EVs, we selected four lncRNA genes: GAS5, SNHG9, SNHG11 and SNHG15, along with LAMC2—a protein coding gene, whose high expression has been associated with metastasis and poor prognosis in some cancers including PM [49]—for additional validation using EVs isolated from three non-PM cell cultures (Table S10). The gene discussed is SNHG15; the disease is cancer.