RORB and Alzheimer disease: By contrast, scRNAseq performed on postmortem AD patients identified glutamatergic neurons in layer II of the entorhinal cortex9, and in particular those expressing the gene RORB11, to be especially susceptible to τ. We also did not find a notable positive association between the baseline expression of Rorb in the mouse brain and τ pathology (Fig. Fig. 4); likely, this is due to the fact that Rorb is also a marker of L4 glutamatergic neurons in the cortex and τ pathology in these datasets is lower in cortical areas than in limbic structures (Fig. S7).