Taking a broader perspective on the interactions between gene expression and the development of AD-associated pathology may be required; for instance, Sepulcre, et al. examined propagation patterns of τ and amyloid-β (Aβ) and found associations for hundreds of genes previously unknown to be associated with AD, utilizing transcriptomic data from the Allen Human Brain Atlas5,6. The gene discussed is TBXT; the disease is Alzheimer disease.