To mimic this cytokine downregulation, blocking their cognate receptor, CXCR3, reduced immune cell infiltration and promoted tumour growth. Reviewing RNA-seq data from ARID1A heterozygous organoids revealed that CXCL11 and CXCL10 were the most highly downregulated chemokines, though this did not achieve significance after multiple hypothesis testing correction (Fig. 5J). This evidence concerns the gene ARID1A and neoplasm.