CXCR3 and neoplasm: To mimic this cytokine downregulation, blocking their cognate receptor, CXCR3, reduced immune cell infiltration and promoted tumour growth. Reviewing RNA-seq data from ARID1A heterozygous organoids revealed that CXCL11 and CXCL10 were the most highly downregulated chemokines, though this did not achieve significance after multiple hypothesis testing correction (Fig. 5J).