ACACA and steatosis: As overexpression of ACC1 or PC caused steatosis in wild-type hepatocytes (Fig. EV5A–C) and that the ACC1 inhibitor TOFA or the ACC1 shRNA ameliorated the steatosis in KIF12-deficient hepatocytes (Fig. EV5D,E), the causal relationship between the upregulation of those enzymes and the MASH pathology appeared to be very evident.