Because ADX mice die early after LCMV infection34 these experiments were performed at day 4 p.i. Notably pDCs were equally suppressed in their IFNα production capacity in the spleens of ADX and SHAM mice suggesting glucocorticoids do not play a major role in the establishment of pDC inhibition after infection (Supplementary Fig. 1). The gene discussed is IFNA1; the disease is infection.