Inhibition of the EGFR leads to AMPK activation, which phosphorylates ACC and suppresses regeneration-associated lipid accumulation.374,452,453 Additionally, EGFR inhibition in a NAFLD-associated steatosis model similarly results in reduced expression of core lipid metabolism enzymes, potentially regulated by the transcription factors ChREBP, SREBF1, PPARγ, and HNF4α. This evidence concerns the gene PPARG and steatosis.