FOXO1 and Insulin resistance: Additional KO of FOXO1 in AKT-deficient mice restores Cyclin D1 expression and reverses the impaired capacity for liver regeneration after PHx.398,399 Recent findings have uncovered the upstream mechanism by which mTORC2 is involved in partially regulating AKT1/2 kinase activity.400,401 Coupled with its role in regulating cell proliferation, AKT signaling is involved in regulating glucose homeostasis and lipid metabolism.402–405 The liver-specific deletion of both AKT1 and AKT2 inhibits hepatocyte proliferation along with glucose intolerance and insulin resistance.