PPARγ, activated by various arachidonic acid metabolites, is expressed at relatively low levels in the liver.558 PPARγ has been shown to delay liver mass restoration in the later stages of liver regeneration after PHx.564 Studies indicate that hepatic PPARγ expression contributes to steatosis by promoting triglyceride synthesis and impairing glucose tolerance through monoacylglycerol O-acyltransferase 1 (MGAT1).565 Liver-specific Pparγ-deficient mice exhibit an enhanced capacity for liver regeneration, mediated by the HGF/c-Met/ERK1/2 signaling pathways.566,567. Here, PPARG is linked to steatosis.