TGFB1 and Hepatic fibrosis: Specifically, although the excessive accumulation of myofibroblasts (MFs) leads to defective repair and liver fibrosis, transient HSC-derived MFs are important for replacing the large amount of parenchymal cells that were lost, especially in the context of chronic liver injury.349 TGF-β stimulation allows HSCs to exhibit LPC features via the Jagged1/Notch pathway.350,351 Additionally, TGF-β signaling drives compensatory hepatocyte-mediated cholangiocyte transdifferentiation to reconstruct the intrahepatic biliary system in mice with NOTCH signaling defects.352