Many studies indicate that appropriate, transient regeneration-associated steatosis (TRAS) is a universal feature of regenerating livers, recognized as an essential process for the initial phases of liver regeneration.418,443,448 Nuclear receptor corepressor 1 (Ncor1), a comprehensive nuclear receptor inhibitory gene, regulates the crosstalk among several nuclear proteins related to metabolism.449–451 Hepatic NCOR1 deficiency results in increased hepatocyte proliferation and downregulated P27 expression following PHx. Here, NCOR1 is linked to steatosis.