Inhibition of the EGFR leads to AMPK activation, which phosphorylates ACC and suppresses regeneration-associated lipid accumulation.374,452,453 Additionally, EGFR inhibition in a NAFLD-associated steatosis model similarly results in reduced expression of core lipid metabolism enzymes, potentially regulated by the transcription factors ChREBP, SREBF1, PPARγ, and HNF4α. The gene discussed is EGFR; the disease is steatosis.