DNAJC15 and Insulin resistance: Silencing MCJ can reprogram glycolipid metabolism, improve insulin resistance, and alleviate hepatic steatosis, even overcoming the regenerative limitations in aged livers.607 Additionally, the absence of MCJ reduces ROS production, amplifying antioxidant defenses.613 This is consistent with previous findings that overactive mitochondrial activity often leads to excessive ROS generation, which exacerbates liver damage.614–616