Indeed, Ang II–infused hypertension in wild-type mice was associated with a 2-fold decrease in vascular nitric oxide and impaired endothelial-dependent vasorelaxation (Figure 4C and D), while depletion of smooth muscle CypD in SmcCypDKO mice partially protects nitric oxide levels and acetylcholine-induced relaxation (Figure 4C and D; logEC50 [SmcCypDKO] = 7.3 and logEC50 [SmcCypDKO + Ang II] = 6.7). The gene discussed is AGT; the disease is hypertensive disorder.