AGT and hypertensive disorder: We have recently shown that protection from mitochondrial oxidative stress preserves endothelial-dependent relaxation in mesenteric arteries in the Ang II model of hypertension.35 Meanwhile, the recovery of endothelial function may vary due to distinct metabolic conditions of these vessels60 and differences in the regulation of endothelial-dependent dilation.61 Future studies are needed to define the role of CypD in the pathophysiological alterations of relaxation/contraction of resistant vessels and microvasculature.