Unfortunately, breeding transgenic mice with inducible SMMHC Cre located in the Y chromosome provides only SmcCypDKO male mice.23 A new smooth muscle tamoxifen-inducible Cre mice with Myh11-driven smooth muscle cells expression integrated in chromosome 2 (Jackson Laboratory, strain # 037658) allows studies in both male and female mice.52 Previous animal studies showed attenuated Ang II–induced hypertension in female mice compared with male littermates.53 This makes it difficult to study the protective effect of CypD depletion in females, which have already significant protection. The gene discussed is AGT; the disease is Hypertension.