MAPT and Alzheimer disease: AD involves intricate neuropathologic mechanisms, including the accumulation of extracellular Aβ plaques and the formation of intracellular neurofibrillary tangle with phosphorylated tau protein.8 Neuroinflammation is increasingly recognized as a potential target for AD.9 Inflammatory markers in CSF, plasma, and postmortem brain tissue of patients with AD underscore the significance of inflammatory process in AD.8,9 Furthermore, most cases of dementia are of mixed etiology, encompassing both vascular and neurodegenerative components.