A greater proportion of the genes in the sparse gcPC1, 2 gene list have been previously implicated in T2D (Fig 4J), including TNFRSF12A [34], TFF3 [35], IMMP2L [36], DDIT3 [28,29], PPP1R1A [37]), and TMEM163 [38]. Here, DDIT3 is linked to type 2 diabetes mellitus.