Among NHW participants, rare variants within ZFP42 mapping to three transcripts (ENST00000326866, P = 1.3E-05; ENST00000509524, P = 1.3E-05; ENST00000618147, P = 1.3E-05; S6 Table) were the top regions associated with co-morbid GERD and COPD. The gene discussed is ZFP42; the disease is gastroesophageal reflux disease.