One variant (7:14108277), intergenic to ETV1 and DGKB, was significantly associated with comorbid GERD and COPD in the single variant analysis [OR = 1.86, 95% CI = 1.66–2.08, P = 3.08E-08, S5 Table] and in meta-analysis [OR = 1.89, 95% CI = 1.67–2.08, P = 2.47E-08, S5 Table] at levels withstanding GWS. This evidence concerns the gene ETV1 and gastroesophageal reflux disease.