We have used three multivariate logistic regression models to show the relationship between CRP level with chronic pain in Table 3: model 1, no covariate was adjusted; model 2, age, and gender were adjusted; model 3, age, gender, race, BMI, education level, PIR, smoking status, diabetes, stroke, lung disease, CHF, CVD, cancer or malignancy, opioids use, NSAIDs use, statins use, WBC, RBC, PLT, and BNP were adjusted. The gene discussed is NPPB; the disease is diabetes mellitus.