Moreover, utilizing ssGSEA with 255 published characteristic gene sets, we observed positive correlations between SEPN1 expression and macrophages, release of cancer cell antigens, infiltration of immune cells into tumors, and exosomal secretion, while negative correlations with sirtuin nicotinamide metabolism and taurine and hypotaurine metabolism (Fig 4I). The gene discussed is SELENON; the disease is cancer.