SRC proto-oncogene, non-receptor tyrosine kinase (Src) is a node of convergence for receptor mediated signaling pathways, activating substrates in the MAPK, JAK/Stat3, and PI3K/AKT pathways to promote tumor cell survival, proliferation and invasion in various cancers, including GBMs [40]. This evidence concerns the gene AKT1 and neoplasm.