BAALC binder of MAP3K1 and KLF4 (BAALC), a regulator of developing neuroectoderm tissues overexpressed in acute leukemia and GBM [58], and a target of SOX2 in differentiated GBM cells [26], was upregulated in HF2303 SDCs (Fig 7C). Here, SOX2 is linked to acute leukemia.