HNF1B and systemic lupus erythematosus: Similarly, we analyzed the cluster 5 cells and detected HNF1B as the only statistically significant TF with hyper-activation in the SLE cases, whereas among the various hypo-active TFs, the most prominent ones were MYC, NFKB, RFXAP, RFX5, and TP53 (Fig. 5E).