A positive AD tau pattern shows neocortical uptake in posterolateral temporal, occipital, or parietal/precuneus regions in both hemispheres, with or without frontal activity in more advanced disease (according to Braak and Braak stages) [33, 34] On the other hand, a negative AD tau pattern is defined when there are no neocortical tau deposits but normal uptake in the midbrain, caudate, putamen, pallidum and thalamus is present [2, 16] or with increased neocortical uptake isolated to the mesial temporal, anterolateral temporal, and/or frontal regions [33]. The gene discussed is MAPT; the disease is Alzheimer disease.