In terms of etiopathogenesis, AI has recently made a significant contribution to our understanding of AD by identifying a new, unidentified etiologic factor that promotes skin inflammation in the paired related homeobox-1 (Prx1)+ fibroblastic subpopulation by overexpressing eotaxin-1: dysregulation of the inhibitor of nuclear factor kappa B kinase subunit beta-nuclear factor kappa-light-chain-enhancer of activated B cells (Ikkb-NF-kB) axis (Sivamaruthi et al. 2023). This evidence concerns the gene PRRX1 and Alzheimer disease.