CEACAM6 and familial pancreatic carcinoma: Pandey et al. further elucidated the potential impact of CD66c knockout in pancreatic cancer cell line (HPAF-II) and found that knockout of CD66c could profoundly impact extracellular matrix (ECM) functions including cell adhesion, immune environment, autophagy, DNA repair, chromatin modifications, and signal transduction [40].