On the other hand, the expression of Iba1/CD206 double positive cells, which identify the anti-inflammatory “alternatively-activated” microglia, was increased in the hippocampus of 3xTg-AD mice treated with anti-TNFSF10 antibody, compared to untreated 3xTg-AD mice (Fig. 2). Here, AIF1 is linked to Alzheimer disease.