TNFSF10 and Alzheimer disease: Among these, TNFSF10, a proapoptotic/proinflammatory cytokine belonging to the TNF superfamily, has been shown to modulate the immune response in AD brain, where it directly mediates Aβ neurotoxicity and, on the other hand, sustains neurodegeneration-related neuroinflammation (Burgaletto et al. 2020).