Therefore, with the aim to understand whether treatment with anti-TNFSF10 monoclonal antibody could affect immune exhaustion, the expression of either CD4+PD1+ T cells as well as CD8+PD1+ T cells was studied in spleen samples of vehicle- and anti-TNFSF10-treated 3xTg-AD mice by means of flow cytometry. The gene discussed is TNFSF10; the disease is Alzheimer disease.