In this line, our study further supports the role of the spleen as a source of Ly6Chigh monocytes in the AD pathology, with a highly represented proinflammatory Ly6Chigh monocytes population in the spleen of 3xTg-AD mice, reduced upon anti-TNFSF10 mAb treatment. Here, TNFSF10 is linked to Alzheimer disease.