IL6 and disease of the tendon: In contrast to the signatures emerging from the presence of fibroblasts however, the respective contribution of transcripts increased and decreased by the IL-6 KO to the enriched GO biological processes and molecular functions indicates a decreasing cellularity and ECM turnover in the core (Figure 9—figure supplement 1), which could mean that IL-6 signaling contributes to the gene expression behind these tendinopathy hallmarks.