STING pathway activation was enhanced by both TAK-500 and mTAK-500 (EC50 = 0.4170 nmol/L and EC50 = 0.3393 nmol/L, respectively) compared with unconjugated dazostinag at the same molar equivalents (EC50 = 1,646 nmol/L and EC50 = 892.7 nmol/L) in human THP1 AML cell reporter cells (Fig. 1C). This evidence concerns the gene STING1 and acute myeloid leukemia.