As shown in Fig. 5C, combining low-dose mTAK-500 (5 μg/kg) with 8-Gy radiation enhanced the efficacy in CT26 tumor–bearing mice (GRI 88%; P < 0.001) when compared with either mTAK-500 or radiation alone (GRI 8%; P = 0.2 and GRI 68%; P < 0.001, respectively). Here, DDX53 is linked to neoplasm.