As depletion of key immune cell populations, such as DCs or CD8+ T cells, could be counterproductive to driving antitumor activity, it is important to note that this is transient and observed only in the periphery and not in the TME of tumor-bearing mice and that the depletion of MDSCs and TAMs did not impact mTAK-500–driven efficacy in tumor-bearing mice. Here, CD8A is linked to neoplasm.