RALA and hereditary disease: Deleterious variants in the RALA gene have recently been associated with a syndrome characterized by neurodevelopmental and musculoskeletal abnormalities (Table 1) (Sugihara et al. 2002; Scala et al. 2021; Hiatt et al. 2018; Okamoto et al. 2019) This rare genetic disorder caused by RALA gene variants affects various aspects of an individual's development such as developmental delay, intellectual disability, and speech impairment (Sugihara et al. 2002; Scala et al. 2021; Tzima 2006; Nishiyama 2019).