Secretion, diffusion, and degradation-related parameters for both TNFα and IFNγ seem to be the driving forces behind early initial contact between infected macrophages and CD4+ T cells and strong cytokine signals within granulomas that lead to more activated macrophages, more activated CD4+ T cells, quicker granuloma formation, and more bacterial control in LTBI simulations. This evidence concerns the gene CD4 and Granuloma.