This suggests that a small difference in activated CD4+ T cells in the first few days following infection has a large impact on the availability of IFNγ (both the total amount [Fig. 2e] and number of grid squares above the threshold for STAT1 macrophage activation [Fig. S5 at https://doi.org/10.5281/zenodo.13844841]) which is the limiting factor to complete macrophage activation. The gene discussed is CD4; the disease is infection.