To gain mechanistic insights into the microbial-derived pathways underlying the protective colitis phenotype that was observed in CH-Mgat5−/− mice, an unstratified pathway output of Picrust2 analysis based on 16S rRNA data of SH-Mgat5−/− and CH-Mgat5−/− mice was performed (Figure 4(a)). The gene discussed is MGAT5; the disease is colitis.