The results showed an increased expression of claudin-1 and −2 in Mgat5−/− mice (Figure 1(m,n)), as described to occur in IBD,51,52 alongside a marked loss of sealing claudins −3 and −4 in comparison with Mgat5WT mice (Figure 1(o,p)). The gene discussed is MGAT5; the disease is inflammatory bowel disease.