NOD2 is an intracellular pattern recognition receptor present in most intestinal immune and epithelial cells, and is known to recognize glycans, such as bacterial peptidoglycans, being involved in IBD immunopathogenesis.59 Accordingly, we also observed that the downregulation of IL-22-producing ILC3 imposed by glycan alterations was associated with decreased expression of Fut2-mediated fucosylation and with susceptibility to inflammation, despite we found only a slight decrease in UEA-I binding. Here, IL22 is linked to inflammatory bowel disease.