PRKAA1 and Mitochondrial myopathy: Taken together, the experimental findings in Figs 4, 5, 6, 7, 8 indicate that specific AMPK activation using A‐769662 has a beneficial impact on mitochondrial function as assessed by MMP both in the Flp‐In T‐REx 293 model system with severe mtDNA depletion and in mitochondrial myopathy‐associated cells (Figs 4C, 8B).