PRKAA1 and Mitochondrial myopathy: However, since A‐769662 treatment increased MMP also in uninduced control cells as well as in fibroblasts from mitochondrial myopathy patients and healthy controls where no mtDNA increase was observed (Figs 4, 8), we conclude that the stimulation of mtDNA copy number is not the general mechanism through which A‐769662‐mediated activation of AMPK stimulates MMP.