VEGFA and endothelial dysfunction: Soluble Flt-1 (sFlt-1), also called soluble vascular endothelial growth factor (VEGF) receptor 1, is a soluble form of the VEGF and placental growth factor (PLGF) receptor, and plays a key role in decreasing levels of free PLGF and VEGF, causing endothelial dysfunction (67).