The TgF344-AD rat model expresses familial AD mutations (APPSwe and PS1ΔE9) and displays all the main pathophysiological features of AD such as age-dependent amyloid and tau pathology, neuroinflammation, alterations of brain connectivity, and cognitive impairments.21, , , , , , –28 Data on brain metabolism in TgF344-AD rats are however scarce. The gene discussed is MAPT; the disease is Alzheimer disease.