For instance, cyclin-dependent kinase 3 (CDK3) belongs to the CDK family which regulates the phosphorylation of cyclins, resulting in cell cycle regulation (29).CDK2/4/6 belonging to the same family as CDK3 have been reported as disease-related variants for rheumatoid arthritis (30), which has similarities to periodontitis in terms of its manifestation of bone destruction via inflammation. Here, CDK2 is linked to periodontitis.