TGFB1 and type 2 diabetes mellitus: As these proteoglycans possess pivotal roles in the initiation and progression of bone mineralisation, through the regulation of collagen fibrillogenesis, mineral deposition, crystal growth, TGF-β1 bioavailability and osteogenic cell signalling; such manifestations could additionally impact on normal bone mineralisation events in T2DM bone (108–110, 171).