Amelioration of the detrimental impact of hyperglycaemia on osteogenic dysfunction has been reported to be mediated through Nrf2 activation via the Akt/glycogen synthase kinase 3β (GSK3β)/FYN axis and the restoration of SIRT1 expression in MSCs and osteoblasts (236, 237). The gene discussed is AKT1; the disease is Hyperglycemia.