CXCL8 and periodontitis: Deficiencies in vitamin D have been associated with chronic diseases such as periodontitis and diabetes and with tooth decay (48–50), Extensive studies have explored the anti- inflammatory properties of vitamin D inflammation; vitamin D inhibits the production of pro-inflammatory cytokines like IL-6 and IL-8, which are involved in acute inflammation, while promoting the expression of the anti-inflammatory cytokine IL-10.