NLRP3 and depressive symptom measurement: From the perspective of anxiety and depression treatment, the potential of diet-induced ketosis to inhibit NLRP3 activity in the brain is interesting because there is increasing evidence that stress-mediated activation of this inflammasome precipitates or exacerbates anxiety and depression symptoms, whereas its inhibition results in their amelioration or, in certain cases, termination (Iwata et al., 2016).