MAP2K7 and pemphigus foliaceus: Markers of apoptosis (BCL2 and BAX), estrogen signaling (ER), and Ras signaling (Raf, MEK, and ERK) were activated in the PDF-induced group, as evident from the lower expression of BAX and higher expression of BCL2, ER, p-Raf/Raf, p-MEK/MEK, and p-ERK/ERK, while treatment with QXHZF reversed these changes in signaling molecules, ultimately mediating inhibition of PDF-induced PF.