positive associations with STAI scores for KTR ratio at 15 weeks’ gestation, IL-6 and covariate-adjusted IP-10 and Trp/Kyn ratio at 20 weeks’ gestation.IBS (maternal anxiety), Trp levels significantly decreased in the high-scoring group compared with moderate- (–707.88 ± 289.38 ng/ml, p = 0.044) and low-scoring groups (–1111.14 ± 380.08 ng/ml, p = 0.013).(Maternal depression, EDPS):, Kyn concentrations significantly higher in the in the low-scoring group compared with moderate- (34.2 ± 12.13 ng/ml, p = 0.017) and high-scoring groups (40.89 ± 14.13 ng/ml, p = 0.014). The gene discussed is IL6; the disease is major depressive disorder.