NLRP3 and autoimmune hepatitis: Cucurbitacin E glucoside (CuE), a tetracyclic triterpene glycoside isolated from Cucurbitaceae plants, inhibits oxidative stress by enhancing the SIRT1/Nrf2/HO-1 pathway while suppressing NF-κB/NLRP3 signaling, demonstrating considerable liver protective effects against Con A-induced AIH (Mohamed et al., 2022).