CASP1 and metabolic dysfunction-associated steatohepatitis: In mouse models with NLRP3, ASC, and caspase-1 knockouts, the hepatocyte death, inflammation, and fibrosis induced by an HFD were all mitigated, further demonstrating the pivotal role of the NLRP3 inflammasome in the pathogenesis of MASH (Wree et al., 2014; Stienstra et al., 2011; Dixon et al., 2013).