TINAGL1 and gastric cancer: Several of the detected proteins are also upregulated in other inflammatory intestinal diseases: extracellular matrix protein 1 (ECM1), which was reported to be elevated in inflammatory bowel disease54 and tubulointerstitial nephritis antigen like 1 (Tinagl1), a matricellular protein with protease activity upregulated in gastric cancer and involved in MMP regulation55.