STAT3 and neoplasm: The protein levels of JAK2, STAT3, EZH2, RICTOR, and the phosphorylation levels of STAT3 (Y705), PI3K, AKT (S473), and AKT (T308) were upregulated in NCAPD3 overexpression xenograft tumor, while the total protein levels of PI3K and AKT had no changes (Figure 6D).