NCAPD3 increases the expression of STAT3 and recruits more STAT3 to the promoters of JAK2 and EZH2 genes in PCa, and then results in the upregulation of AKT phosphorylation (T308/S473) via activating JAK2/PI3K and EZH2/NSD2/mTORC2 pathways. Here, AKT1 is linked to posterior cortical atrophy.