We then explored the relationship between HLA-DMB expression and cancer prognosis, finding that high expression levels in CESC (cervical squamous cell carcinoma), LUAD (lung adenocarcinoma), MESO (mesothelioma), SERC (renal cell carcinoma), SKCM (renal cell carcinoma), and UCEC were associated with better clinical outcomes. This evidence concerns the gene HLA-DMB and renal cell carcinoma.