HIF1A and head and neck squamous cell carcinoma: The HIF-1α inhibition significantly promoted the MMP in rSCC-61 cells along with the survival tests shown in Fig. 4(d), which confirmed that the HIF-1α inhibitor (YC-1) could potentially radio-sensitize the HNSCC cells, a finding that supports future therapeutic investigations.31 It was interesting to observe that the HIF-1α inhibition further enhanced glucose uptake in rSCC-61 cells in our study.