Earlier studies reported that radiation induces HIF-1α overexpression to promote glycolysis in radioresistant lung cancer cells that may help them escape from the RT.9,31 These RT-induced metabolic events in rSCC-61 cells may well be caused by the observed HIF-1α overexpression as HIF-1α inhibition modulated the metabolic changes induced by radiation. The gene discussed is HIF1A; the disease is lung cancer.