Additionally, ROC curve analysis indicated that PLAC8 (AUC: 0.887), S100A8 (AUC: 0.818), and PPBP (AUC: 0.871) may serve as valuable biomarkers for IC/BPS patients (Figures 5F–H). This evidence concerns the gene S100A8 and Bartsocas-Papas syndrome 1.