NCF1 and Splenomegaly: This association is further supported by experimental data from NCF1-His90 knock-in (KI) mice, which exhibit reduced oxidative burst, diminished macrophage efferocytosis, splenomegaly, increased type I interferon (IFN-I) scores, and higher levels of plasma cells, as well as enhanced Pristane-induced kidney disease compared to wild-type littermates (11).