Genetic association studies have identified the GTF2I-NCF1 intergenic region on chromosome 7 as a significant susceptibility locus for various autoimmune disorders, including primary Sjögren’s syndrome (pSS) (1, 2), systemic lupus erythematosus (SLE) (3, 4), rheumatoid arthritis (5), systemic sclerosis (SSc) (6), and neuromyelitis optica spectrum disorder (NMOSD) (7, 8). Here, GTF2I is linked to systemic sclerosis.