AKT1 and neoplasm: In addition, the ablated tumor margins also lead to several signaling pathways, activation of the PI3K/Akt signaling pathway, generation of PIP3, which in turn activates Akt and exerts an anti-apoptotic effect by phosphorylating a variety of downstream target proteins (e.g., Bcl-2-associated death-promoting proteins, mammalian target proteins of rapamycin) (10).