ET-1 has a variety of regulatory functions.With a molecular weight of only about 2.5 kDa, it exerts strong vasoconstrictor action on a number of physiological functions and mayslow the development of inflammatory disorders and hypertension [25-27].According to research, people with periodontitis had much greater ET-1 levels in their gingival sulcus exudate (GSE) than healthy GSE[14-18]. This evidence concerns the gene EDN1 and hypertensive disorder.