It was thought that higher expression of TEM8 in tumors was mainly due to angiogenesis within the tumor, however, high TEM8 expression has also been observed in stroma cells like cancer associated fibroblasts (CAFs) and pericytes (Hsu et al., 2022; Kareff et al., 2023) and cancer cells themselves (Hoye, et al., 2018). The gene discussed is ANTXR1; the disease is cancer.