Lastly, it is known that TEM8 is involved in the collagen pathway by facilitating the uptake of collagen VI in cancer stroma, which is key for cancer survival (Hsu, et al., 2022), and in breast cancer, in which Chen, et al. demonstrated that it was involved in collagen trafficking (Chen et al., 2013). The gene discussed is ANTXR1; the disease is breast carcinoma.