STAT3 and neoplasm: This KEGG analysis was also congruent with MSigDB hallmark pathways (Supplementary Table S1), where TGF-beta signaling is within the top 20 pathways associated among other signaling pathways related to aggressiveness of the tumor such as KRAS, TNFalpha signaling pathways and inflammatory responses (IL-6/STAT3, IL-2/STAT5 and IFNgamma pathways).