The new diagnostic criteria include colorectal morphologic cells that exceed 50% of the tumor tissue and are positive for at least one colorectal immunophenotype, including mainly tail homologous box (CDX-2), cytokeratin 20 (CK20), specific AT-sequence binding protein 2 (SATB2), and mucin 2 (MUC2), Villin, clinically excluding colorectal cancer (5, 6). This evidence concerns the gene MUC2 and colorectal cancer.